Niagen IV in Leawood, KS

Medically reviewed by Mark Strehlow, MD, Medical Director — October 2026

Niagen IV is an infusion of nicotinamide riboside, a form of vitamin B3 that your body uses to make NAD+. At Rock Creek Wellness in Leawood, in the Kansas City area, it takes about an hour, and a 500 mg session costs $849. We no longer offer NAD+ IV. Niagen IV replaced it, and this page explains why. It also covers what the research shows, what it doesn’t, and what to expect at your visit. Individual results vary.

At a glance

What it is
An infusion of nicotinamide riboside, a form of vitamin B3 your body uses to make NAD+.
Why Niagen IV
Shorter infusions and fewer side effects during them than NAD+ IV, in published studies.
How it starts
A free consultation, where your provider decides whether Niagen IV makes sense for you.
Time and price
About an hour; from $849 for a 500 mg session.
Who looks after you
Our nurse practitioner, Hannah Osborn, APRN, places your IV and looks after you while it runs.

What is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell in your body. Your cells use it in hundreds of chemical reactions, including the ones that break down food. Your body makes NAD+ from forms of vitamin B3 in your diet and from the amino acid tryptophan.

Researchers are studying whether raising NAD+ levels, with supplements or infusions, makes a difference to health in people. That hasn’t been shown.

What is Niagen IV?

Niagen is the manufacturer’s name for its form of nicotinamide riboside (NR). NR is a form of vitamin B3. Once it’s inside your cells, they turn it into NAD+.

Our Niagen IV is compounded at an FDA-registered 503B outsourcing facility, a type of compounding pharmacy. It isn’t an FDA-approved drug, and the facility’s FDA registration isn’t an approval of the product.

At our clinic, the dose is added to IV fluid by a physician, or by a registered nurse while a physician is on site, following that physician’s written procedure. That’s what Kansas requires: adding anything to IV fluid counts as compounding a drug, and a nurse may do it only under a physician’s direct supervision and orders. The rest of the rules we follow are on our IV therapy page.

Why we offer Niagen IV instead of NAD+ IV

We used to offer NAD+ IV. We stopped, and we offer Niagen IV instead, for three reasons that published research supports.

  • Shorter infusions. In a 2024 pilot study, Niagen IV took about a quarter of the time of NAD+ IV at the same 500 mg dose. In a 2026 review of clinic records, Niagen IV infusions averaged 37 minutes, compared with 97 minutes for NAD+ IV.
  • Fewer side effects during the infusion. In both studies, people having NAD+ IV commonly had nausea, stomach cramping, diarrhea or chest tightness while it ran. People having Niagen IV mostly felt tingling, and their symptoms were fewer and milder.
  • Blood NAD+ levels. In the 2024 pilot, blood NAD+ was higher 3 hours after a Niagen IV than after an NAD+ IV. It peaked about 21% above where it started. NAD+ IV didn’t raise blood NAD+ in the first 24 hours.

The limits of this research matter just as much:

  • The 2024 study was small: 53 people across two parts. It’s a preprint, which means it hasn’t been through peer review. ChromaDex, the company that makes Niagen (now called Niagen Bioscience), funded it, and four of its authors worked for the company.
  • The 2026 study looked back at the records of 14 clients of a chain of IV clinics. Its authors worked for that chain, and the Niagen was donated by the manufacturer.
  • Both studies measured blood levels, side effects and how long the infusions took. Neither measured whether people felt or functioned differently, or any effect on health.
  • Both used 500 mg. We haven’t found a published study of a higher IV dose.

So we won’t tell you that Niagen IV does more for you than NAD+ IV did, or that it does anything for your health. What the research supports is narrower: it’s a shorter infusion, people have fewer side effects during it, and in the one controlled study it raised blood NAD+ for several hours.

Who it’s for and who it isn’t

Niagen IV is for adults aged 21 and over who want an infusion that raises their NAD+ levels, and who understand what the research does and doesn’t show. You don’t need to be a Premier Care member.

It isn’t for everyone:

  • Pregnancy. We don’t give IV infusions to pregnant women, and we don’t take on new patients who are pregnant or breastfeeding.
  • Conditions the studies left out. The published IV studies excluded people with diabetes or insulin resistance, a seizure disorder, kidney or liver disease, heart disease, cancer or Parkinson’s disease. If you have one of these, there’s no IV research that applies to you, and your provider may advise against it.
  • Heart or kidney problems, or high blood pressure. Any IV adds fluid, which can strain your heart and kidneys.
  • Anyone looking for a treatment. Niagen IV isn’t a treatment for any disease or symptom. If something is wrong, we start by looking for the cause.
  • Athletes who are drug-tested. Anti-doping rules prohibit IV infusions of more than 100 mL in 12 hours outside hospital care, unless you have an approved exemption. Check with your anti-doping agency first.

Your provider goes through all of this with you and will tell you if Niagen IV isn’t a good idea for you.

What to expect at your visit

  1. Consultation first. One of our providers sees you: your own provider if you’re already our patient, and usually our nurse practitioner, Hannah Osborn, APRN, if you’re new. They go through your health history, medicines and goals, decide whether Niagen IV makes sense for you and at what dose, and write a prescription for you. The consultation is free.
  2. Your dose. 500 mg is our standard dose, and the dose the published IV studies used. Your provider may prescribe 1,000 mg instead when they judge it right for you, but less is known about it.
  3. Vital signs. We check your blood pressure, pulse and other vital signs before the infusion and again when it ends.
  4. The infusion. Our nurse practitioner, Hannah Osborn, APRN, places the IV in your arm and looks after you while it runs, which takes about an hour. You’ll feel a brief pinch when the IV goes in. After that, you can read, work or rest. If the tingling bothers you, tell us and we’ll slow the drip.
  5. Afterward. You can usually go straight back to your day.

Niagen IV cost

Option Price
Niagen IV 500 mg, one session $849
Niagen IV 1,000 mg, one session $1,499
Niagen IV series: four 500 mg sessions $2,880 ($720 a session)

The series is for 500 mg sessions only, used within 6 months of purchase. If you stop early, we refund what you paid, minus the single-session price ($849) for each session you’ve had. For example, if you’ve had one session, we refund $2,031. Each session still starts with a check by your provider.

Premier Care members receive their member discount on single IV sessions. It doesn’t apply to the series price or to specials.

Niagen IV is cash-pay and isn’t covered by insurance. We accept HSA and FSA cards; your plan decides what qualifies.

Request a free consultationor call (913) 727-7700

Risks and side effects

  • The IV site. Any IV can cause bruising, soreness or irritation of the vein. Less often, the site becomes infected or a blood clot forms.
  • During the infusion. In the studies, people having Niagen IV most often felt tingling in the mouth, jaw, arms, hands or feet. Some felt cold, pressure in the head or ears, or a stuffy or runny nose, and a few had mild nausea or cramping. These stopped when the infusion ended, and they were stronger when it ran faster.
  • Fluid. The extra fluid can strain your heart and kidneys if they’re already under strain.
  • Allergic reactions can happen and, rarely, can be severe.
  • Higher doses. We haven’t found published research on IV doses above 500 mg, so less is known about 1,000 mg.
  • The days after. Call us if the IV site becomes red, hot, swollen or more painful, or if you get a fever.

Common questions

What is a Niagen IV for?

It’s for raising your NAD+ levels. It gives your body nicotinamide riboside, which your cells turn into NAD+. In the one controlled study, blood NAD+ peaked about 21% above where it started, 3 hours after the infusion. Research hasn’t yet shown what, if anything, that higher level does for your health.

How much does a Niagen IV cost?

At our clinic, $849 for 500 mg and $1,499 for 1,000 mg, or $2,880 for a series of four 500 mg sessions.

How often can I have one?

There’s no evidence-based schedule. The studies tested a single infusion, and four infusions on four days in a row. Your provider decides with you.

How long until it works?

The honest answer is that the studies measured blood levels, not how people felt. In the controlled study, blood NAD+ was highest about 3 hours after the infusion and had fallen most of the way back by two weeks. We can’t tell you when, or whether, you’ll notice a difference.

Is Niagen IV the same as NAD+ IV?

No. NAD+ IV infuses NAD+ itself. Niagen IV infuses nicotinamide riboside, which your cells turn into NAD+. We no longer offer NAD+ IV.

Can I take Niagen as capsules instead?

Yes. Nicotinamide riboside is also sold as Tru Niagen capsules, which we sell at the clinic and through our online store (see our supplements page). We earn money on these sales. Nicotinamide riboside taken by mouth has been studied far more than the IV form. Ask your provider which makes sense for you.

Does insurance cover it?

No. Niagen IV is cash-pay. We accept HSA and FSA cards; your plan decides what qualifies.

Book a Niagen IV consultation

Book a free consultation and select IV Therapy as the reason for your visit, or call (913) 727-7700. You can see our other IVs, with their ingredients and prices, on our IV therapy page.

This page is educational and is not medical advice. Individual results vary.

Sources (7)
  1. Hawkins J, Idoine R, Kwon J, et al. Randomized, placebo-controlled, pilot clinical study evaluating acute Niagen+ IV and NAD+ IV in healthy adults. medRxiv (preprint, not peer reviewed) 2024. doi:10.1101/2024.06.06.24308565
  2. Reyna K, et al. Intravenous infusion of nicotinamide adenine dinucleotide (NAD+) versus nicotinamide riboside (NR): a retrospective tolerability pilot study in a real-world setting. Frontiers in Aging 2026. PMC12907335
  3. Cercillieux A, Ciarlo E, Cantó C. Balancing NAD+ deficits with nicotinamide riboside: therapeutic possibilities and limitations. Cellular and Molecular Life Sciences 2022. PubMed
  4. ChromaDex. Pharmaceutical-grade intravenous and injectable Niagen, compounded by an FDA-registered 503B outsourcing facility. 2024. BusinessWire
  5. Bonate PL, Prokopienko AJ, Gries JM; ACCP Public Policy Committee. ACCP Position Statement on Hydration and Vitamin Infusion Clinics. Journal of Clinical Pharmacology 2024. doi:10.1002/jcph.2364
  6. Kansas State Board of Healing Arts and Kansas Board of Pharmacy. Joint Statement Regarding Intravenous Therapy. February 2026. ksbha.ks.gov
  7. U.S. Anti-Doping Agency. Is it prohibited for athletes to use IV infusions for rehydration and recovery? USADA Spirit of Sport. usada.org